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Creators/Authors contains: "Sundarkumar, V"

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  1. Providing drug products for pediatric patients is a challenging problem for the pharmaceutical industry. Children often require flexible low-dose medication with features like taste-masking and ease of swallowing. In recent years, mini-tablets have emerged as an attractive dosing solution that can meet these requirements. They are small form oral dosages around 2-4 mm in diameter that can be dispensed individually or in combination. Conventionally, they are made using methods like direct compression and hot melt extrusion. This study introduces a new technique to make mini-tablets: drop-on-demand 3D printing. Here the active ingredient is suspended in a liquid excipient, the formulation is printed as droplets and each drop is solidified to yield a mini-tablet. An optimal solvent bath that can uniformly capture mini-tablets is designed and dosages of Atorvastatin (active ingredient) are produced as a test case. Quality of these dosages is determined by measuring their content uniformity. 
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